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Thursday, May 7, 2020 | History

4 edition of Thermodynamics of hydration and stability of nucleic acids found in the catalog.

Thermodynamics of hydration and stability of nucleic acids

Adrian Ho-Yin Lee

Thermodynamics of hydration and stability of nucleic acids

by Adrian Ho-Yin Lee

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  • 3 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 2002.

SeriesCanadian theses = -- Th`eses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative.
ID Numbers
Open LibraryOL21789495M
ISBN 100612688127
OCLC/WorldCa54461077

  Nucleic acid thermodynamics is the study of how temperature affects the nucleic acid structure of double-stranded melting temperature is defined as the temperature at . processes). Although starting with the basics of thermodynamics and kinetics, / progresses to a level suitable as background for more advanced graduate courses or literature work in biophysical areas including protein and nucleic acid stability and interactions, enzyme catalysis and bioenergetics. Books .

"Molecular crowding and hydration regulating of G-quadruplex formation", Quadruplex Nucleic Acids (Springer), , Chap 5, () "Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowing: beyond the Watson-Crick double helix", International Review of Cell and Molecular Biology (Elsevier), , chap 8,   title = "Unfolding thermodynamics of nucleic acids: Determining heat capacity effects using differential scanning calorimetry (DSC)", abstract = " The heat capacity (ΔC P) effects on the unfolding of a macromolecule play a significant role in the magnitude of their standard thermodynamic profiles; all three thermodynamic parameters (enthalpy, entropy and free energy) are dependent on Author: Carolyn E. Carr, Calliste Reiling-Steffensmeier, Irine Khutsishvili, Luis A Marky.

Nucleic acid thermodynamics is the study of how temperature affects the nucleic acid structure of double-stranded DNA (dsDNA). The melting temperature (T m) is defined as the temperature at which half of the DNA strands are in the random coil or single-stranded (ssDNA) state.   Nucleic acid motif thermodynamics. The standard model of nucleic acid hybridization thermodynam26 is a local model, in which the structure of a nucleic acid Cited by:


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Thermodynamics of hydration and stability of nucleic acids by Adrian Ho-Yin Lee Download PDF EPUB FB2

Thermodynamic, Counterion, and Hydration Effects for the Incorporation of Locked Nucleic Acid Nucleotides into DNA Duplexes†Cited by:   (). Hydration Regulates The Thermodynamic Stability Of Dna Structures Under Molecular Crowding Conditions. Nucleosides, Nucleotides & Nucleic Acids: Cited by: Even when true 3D folded structures are formed from nucleic acids, the topology remains simple, with the anionic phosphates forming the surface of the molecule.

Nevertheless, nucleic acids do occur in a variety of structures that includes single strands and high-order duplex, triplex or Cited by: Hydration and stability of nucleic acid bases and base pairs Article (PDF Available) in Physical Chemistry Chemical Physics 9(8) March with Reads How we measure 'reads'.

Hydration represents a major force governing the conformational preferences and drug binding properties of nucleic acids. Volumetric measurements have proven useful in characterizing the hydration properties of nucleic acid structures and their Thermodynamics of hydration and stability of nucleic acids book with other by: The role of thermodynamics in modern physics is not just to provide an approximate treatment of large thermal systems, but, more importantly, to provide an organising set of ideas.

Thermodynamics: A complete undergraduate course presents thermodynamics as a self-contained and elegant set of ideas and methods. It unfolds thermodynamics for undergraduate students of physics, chemistry or. Thermodynamic Parameters To Predict Stability of RNA/DNA Hybrid Duplexes.

Naoki Sugimoto, Shu-ichi Nakano, Conformational Flexibility Influences Degree of Hydration of Nucleic Acid Hybrids. The Journal of Physical Chemistry BHydration Regulates Thermodynamics of G-Quadruplex Formation under Molecular Crowding by: Through the helical periodicity of the nucleic acid structure, those bridges can lead to regular and striking hydration networks involving several water molecules and characteristic of the nucleic.

Hydration of nucleic acid components. The volumetric properties of components of nucleic acids including sugars, nucleic acid bases, nucleosides, and nucleotides have been thoroughly studied,. By investigating these relatively simple compounds, one hopes to gain insight into the hydration properties of nucleic by:   The S hydration site is evolutionarily conserved within the RRM domains.

In conclusion, MD is an effective tool for predicting and interpreting the hydration patterns of protein/RNA complexes. Hydration is not easily detectable in NMR experiments but can affect stability of protein/RNA by: Empirical, quantum chemical calculations and molecular dynamics simulations of the role of a solvent on tautomerism of nucleic acid bases and structure and properties of nucleic acid base pairs are summarized.

Attention was paid to microhydrated (by one and two water molecules) complexes, for which structures found by scanning of empirical potential surfaces were recalculated at a correlated Cited by: A nucleic acid in aqueous solution is in equilibrium between the native conformation and its uncoiled conformation.

The Nucleic acid stability of the native state is based on the magnitude of the Gibbs free energy (∆G) of the system and the thermodynamic relationships between enthalpy (∆H) and entropy (∆S) changes.

A positive ∆G indicates the native state is more stable than the. On the stability of nucleic acid structures in solution: enthalpy-entropy compensations, internal rotations and reversibility.

M S Searle and D H Williams Cambridge Centre for Molecular Recognition, University Chemical Laboratories, by: Abstract. Thermodynamic properties of peptide nucleic acids (PNA) and their complexes with nucleic acids have attracted increasing attention.

More detailed thermodynamic information is desired in order to understand and improve the behavior of PNAs in various contexts, e.g., in the design of polymerase chain reaction (PCR) probes and potentially for the use of PNA in by: 1. Understanding the role water plays in biological processes requires detailed knowledge of the phenomena of biopolymer hydration.

Water molecules are critical to nucleic acid structure and recognition by proteins and small ligands. Thus, understanding the hydration of nucleic acids is a significant problem in biochemistry of DNA and by: 5.

This is “Thermodynamic Stability of the Atomic Nucleus”, section from the book Principles of General Chemistry (v. For details on it (including licensing), click here.

This book is licensed under a Creative Commons by-nc-sa license. Topics covered in this book are protein and nucleic acid folding and stability, enzyme-substrate interactions, prediction of the affinity of complexes, electrostatics, and non-equilibrium aspects of protein function.

The breadth of the topics covered illustrates the growing importance of thermodynamic approaches in the study of biological. One strategy to establish the necessary performance is to introduce nucleotide analogs such as Locked Nucleic Acids (LNAs) into AS probes or primers; however the successful design requires a fundamental understanding of both the thermodynamics and kinetics of LNA-DNA heteroduplexes.

Nucleic Acids Research() Optical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor. ACS Chemical BiologyCited by: Nucleic Acids, Hydration of - CHEMICAL BIOLOGY. Nucleic Acids, Hydration of - CHEMICAL BIOLOGY - reflects the multidimensional character of chemical biology, focusing in particular on the fundamental science of biological structures and systems, the use of chemical and biological techniques to elucidate.

Main page. Little is known, however, about the behaviors of nucleic acids in heterogeneous conditions such as in the presence of liposomes and ionic liquids (ILs). In this chapter, I discuss the effects of liposome and ionic liquid on the structure, stability, and function of nucleic : Naoki Sugimoto.Predicting DNA duplex stability from the base sequence.

Proceedings of the National Academy of Sciences of the United States of America Crossref: Chalikian TV, Volker J, Plum GE, Breslauer KJ ().

A more unified picture for the thermodynamics of nucleic acid duplex melting: a characterization by calorimetric and volumetric.Advanced experimental and computational technologies allow access to more information on lncRNAs. Determining the functions and action mechanisms of these RNAs on a large scale is urgently needed.

We provided lncRNATargets, which is a web-based platform for lncRNA target prediction based on nucleic acid by: